“Saddest anime scene”
I might be weird, because for me it’s a scene from Digimon Adventure, and the English dub might have had a few problems, but keeping the emotion was (usually) not one of them. Toward the end of the series, Kari (Hikari) gets sick and Tai (Taichi) loses his cool before explaining why he’s so protective of her; he tells a story about when they were younger. Especially the part about what Kari says when she comes back home.
It’s from about 2:30 to 4:00 in this video. (No color, but the only other video I could find was in Spanish.)